Glyceric acid → Solketal
Reaction equation
[C:1]([OH:7])(=O)[CH:2]([CH2:4][OH:5])[OH:3].CO[C:10](OC)([CH3:12])[CH3:11].C(O)[C@H](O)C(O)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CO>[CH3:11][C:10]1([CH3:12])[O:3][CH:2]([CH2:4][OH:5])[CH2:1][O:7]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Alternatively, the glyceric acid can be reacted with the 2,2-dimethoxypropane without methanol to prepare 2,3-O-isopropylidene D- or L-glyceric acid which is then reacted with lithium aluminum hydride to produce the solketal.
Sources & evidence
- ORD record
- ord-12372ba251834ee4b61c179f32962dcb
- Source dataset
- uspto-grants-1986_03
- Patent number
- US04575558
Reaction notes
Loading…