4-Hydroxybenzaldehyde → 3,5-Difluoro-4-(4-formyl-phenoxy)benzonitrile

HRID 492559Notes

Reaction equation

HRID 492559 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[C:17]([F:19])[CH:18]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[C:17]([F:19])[C:18]=1[O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[C:14]#[N:15]

Participants

5

Reactant 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 5872043,5-Difluorobenzonitrile

Product 1

HCID 597299063,5-Difluoro-4-(4-formyl-phenoxy)benzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Basic displacement reaction of 4-hydroxy benzaldehyde and 3,5-difluorobenzonitrile using potassium carbonate in anhydrous DMF at reflux temperatures affords the above compound.

Workup

  1. temperatureat reflux temperatures
  2. customaffords the above compound

Sources & evidence

ORD record
ord-ace619661eee4f0da0b3c2ccca9e8ea2
Source dataset
uspto-grants-2009_05
Patent number
US07531557B2

Reaction notes

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