Sodium hydride → (S)-1-(tetrahydro-pyran-4-yl)-pyrrolidine-2-carboxylic acid (3-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-isoxazol-5-yl)-amide

Reaction equation

[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:11][CH2:10][CH2:9][C@H:8]2[C:12]([OH:14])=O)[CH2:3][CH2:2]1.C(N(C(C)C)CC)(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH3:48][C:49]([C:59]1[CH:63]=[C:62]([NH2:64])[O:61][N:60]=1)([CH3:58])[CH2:50][O:51][CH:52]1[CH2:57][CH2:56][CH2:55][CH2:54][O:53]1.[H-].[Na+]>CN(C=O)C>[CH3:58][C:49]([C:59]1[CH:63]=[C:62]([NH:64][C:12]([C@@H:8]2[CH2:9][CH2:10][CH2:11][N:7]2[CH:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[O:14])[O:61][N:60]=1)([CH3:48])[CH2:50][O:51][CH:52]1[CH2:57][CH2:56][CH2:55][CH2:54][O:53]1