2-Bromopyridine → 1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)-4-(pyridin-2-yl)but-3-yn-1-ol
Reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@@H:7]([CH3:10])[CH2:6][C@H:5]1[CH:11]([OH:15])[CH2:12][C:13]#[CH:14])([CH3:3])[CH3:2].Br[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I.C(N(CC)CC)C>[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@@H:7]([CH3:10])[CH2:6][C@H:5]1[CH:11]([OH:15])[CH2:12][C:13]#[C:14][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)([CH3:3])[CH3:2]Participants
6
