Iodoethane → 3,5-Diethoxybenzaldehyde

HRID 547928

Reaction equation

HRID 547928 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1C)[CH:7]=[O:8])[CH3:2].[OH:13][C:14]1C=C(C=C(O)[CH:21]=1)C=O.C(I)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:14]([O:13][C:10]1[CH:9]=[C:6]([CH:5]=[C:4]([O:3][CH2:1][CH3:2])[CH:11]=1)[CH:7]=[O:8])[CH3:21]

Participants

6

Reactant 4

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 943653,5-DihydroxybenzaldehydeHCID 252420583-Ethoxy-4-methylbenzaldehyde

Product 1

HCID 226086163,5-Diethoxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared analogously to 3-ethoxy-4-methyl-benzaldehyde (intermediate B21, vide infra) by reaction of 3,5-dihydroxybenzaldehyde with ethyl iodide in DMF using K2CO3 as base.

Sources & evidence

ORD record
ord-6e1b1b9a97b6446b8d3185117c6cce95
Source dataset
uspto-grants-2011_05
Patent number
US07939661B2

Linked notes

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