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Hydrochloric Acid → HCID 76571403, compound

HRID 556027
Notes
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Reaction equation

HRID 556027 reaction equation
[C:1]([NH:9][C:10](=[CH:15][N:16]([CH3:18])C)[C:11]([O:13][CH3:14])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1[S:21][CH:22]=[CH:23][N:24]=1.Cl.O>C(O)(C)C>[C:1]([NH:9][C:10](=[CH:15][NH:16][C:18]1[S:21][CH:22]=[CH:23][N:24]=1)[C:11]([O:13][CH3:14])=[O:12])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 21552-AminothiazoleHCID 3644677HCID 3644677, compound

Product 1

HCID 76571403HCID 76571403, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

10 g (39.5 mmol) of methyl 2-benzoylamino-3-dimethylaminoacrylate and 11.3 g (118 mmol) of 2-aminothiazole were dissolved at 40° C. in 200 ml of isopropanol. The solution was admixed with 3.96 ml (48 mmol) of concentrated hydrochloric acid within 5 minutes (min) and stirred for a further 60 min. 75 ml of deionized water were added, the suspension was cooled overnight and the crystallized product was filtered off.

Workup

  1. temperaturethe suspension was cooled overnight
  2. filtrationthe crystallized product was filtered off

Sources & evidence

ORD record
ord-bde76aad9cdb406aba7208367ec6a780
Source dataset
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08053590B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes