Sodium Iodide → 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one

HRID 560095

Reaction equation

HRID 560095 reaction equation
[C:1]1([S:7]([N:10]2[CH2:12][CH:11]2[C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-].[Na+].[CH:22]([N:25]=[C:26]=[O:27])([CH3:24])[CH3:23]>O1CCCC1>[C:1]1([S:7]([N:10]2[CH2:12][CH:11]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=3)[N:25]([CH:22]([CH3:24])[CH3:23])[C:26]2=[O:27])(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 61277Isopropyl isocyanateHCID 866371721-Benzenesulfonyl-2-(3-bromo-phenyl)-aziridine

Product 1

HCID 670010961-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to example 1, step 2,1-benzenesulfonyl-2-(3-bromo-phenyl)-aziridine (example 5, step 1) was reacted with sodium iodide and isopropyl isocyanate in tetrahydrofuran to give 1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one as a colorless oil.

Sources & evidence

ORD record
ord-5d290c62e6f5488abde95da348295adc
Source dataset
uspto-grants-2011_11
Patent number
US08063088B2

Linked notes

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