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Triethylamine → (3R,5S)-1-allyloxycarbonyl-5-[1-hydroxy-(imidazo[5,1-b]thiazol-3-yl)methyl]-3-methanesulfonyloxypyrrolidine

HRID 568266
Notes
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Reaction equation

HRID 568266 reaction equation
C(N(CC)CC)C.[CH3:8][S:9](Cl)(=[O:11])=[O:10].[CH2:13]([O:16][C:17]([N:19]1[C@H:23]([CH:24]([OH:33])[C:25]2[N:26]3[CH:32]=[N:31][CH:30]=[C:27]3[S:28][CH:29]=2)[CH2:22][C@@H:21]([OH:34])[CH2:20]1)=[O:18])[CH:14]=[CH2:15].C(=O)([O-])O.[Na+]>C1COCC1>[CH2:13]([O:16][C:17]([N:19]1[C@H:23]([CH:24]([C:25]2[N:26]3[CH:32]=[N:31][CH:30]=[C:27]3[S:28][CH:29]=2)[OH:33])[CH2:22][C@@H:21]([O:34][S:9]([CH3:8])(=[O:11])=[O:10])[CH2:20]1)=[O:18])[CH:14]=[CH2:15]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chloride2×HCID 516892Sodium BicarbonateHCID 70220671(3R,5S)-1-allyloxycarbonyl-3-hydroxy-5-[1-hydroxy-1-(imidazo[5,1-b]thiazol-3-yl)methyl]pyrrolidine

Product 1

HCID 86756315(3R,5S)-1-allyloxycarbonyl-5-[1-hydroxy-(imidazo[5,1-b]thiazol-3-yl)methyl]-3-methanesulfonyloxypyrrolidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Triethylamine (0.165 ml) and 0.080 ml of methanesulfonyl chloride are successively added to 313 mg of crude (3R,5S)-1-allyloxycarbonyl-3-hydroxy-5-[1-hydroxy-1-(imidazo[5,1-b]thiazol-3-yl)methyl]pyrrolidine (stereoisomer B) in 8.5 ml of THF in an argon atmosphere at −14° C., and the mixture is stirred in this state for 40 min. Further, 0.008 ml of methanesulfonyl chloride is added thereto, and the mixture is stirred for 20 min. A 5% aqueous sodium hydrogencarbonate solution (20 ml) is added thereto, and the mixture is extracted wit 50 ml of ethyl acetate. The organic layer is dried over magnesium sulfate and filtered. The solvent is removed by evaporation under reduced pressure to give 355 mg of crude (3R,5S)-1-allyloxycarbonyl-5-[1-hydroxy-(imidazo[5,1-b]thiazol-3-yl)methyl]-3-methanesulfonyloxypyrrolidine (stereoisomer B) as a slight yellow amorphous material.

Workup

  1. stirringthe mixture is stirred for 20 min
  2. extractionthe mixture is extracted wit 50 ml of ethyl acetate
  3. dry with materialThe organic layer is dried over magnesium sulfate
  4. filtrationfiltered
  5. customThe solvent is removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-97d3211958b04b05950a56b255e64a83
Source dataset
uspto-grants-2001_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06180622B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes