p-Toluenesulfonic acid → 2,5,5-Trimethyl-2-propyl-1,3-dioxane
Reaction equation
[CH3:1][C:2](=[O:6])[CH2:3][CH2:4][CH3:5].[CH3:7][C:8]([CH3:13])([CH2:11]O)[CH2:9][OH:10].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1([CH2:3][CH2:4][CH3:5])[O:10][CH2:9][C:8]([CH3:13])([CH3:11])[CH2:7][O:6]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Pentanone, 2,2-dimethyl-propane-1,3-diol, and a catalytic amount of p-toluenesulfonic acid (PTSA) were refluxed in toluene to provide a crude product. Distillation provided the product 2,5,5-trimethyl-2-propyl-[1,3]dioxane.
Workup
- customto provide a crude product
- distillationDistillation
Sources & evidence
- ORD record
- ord-e5d10747c1d04c2695967de07f2120ed
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09441185B2
Reaction notes
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