Potassium Carbonate → 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole
Reaction equation
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH:15]1[CH2:17][CH2:16]1>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[CH:6]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 4-bromo-1H-pyrazole (0.1 g, 0.68 mmol) in DMF (20 ml) were added K2CO3 (0.19 g, 1.36 mmol, 2 eq.) and (bromomethyl)cyclopropane (92 mg, 0.68 mmol, 1 eq.). The mixture was stirred at RT for 4 h. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude product (0.15 g).
Workup
- customThe mixture was quenched
- extractionextracted as in Intermediate Example 5(c)
- distillationThe solvent was distilled off
Sources & evidence
- ORD record
- ord-a167ce228617490a96ee8259ff7c99af
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09447091B2
Reaction notes
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