1,1'-Carbonyldiimidazole → HCID 178517330, compound

HRID 641785

Reaction equation

HRID 641785 reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](N1C=CN=C1)(N1C=CN=C1)=[O:11]>C1COCC1>[Cl:9][C:3]1[C:2]2[NH:1][C:10]([OH:11])=[N:8][C:7]=2[CH:6]=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 2857362-Chloropyridine-3,4-diamine

Product 1

HCID 178517330HCID 178517330, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.1 A solution of 17.23 g of 3,4-diamino-2-chloropyridine and 19.46 g of 1,1′-carbonyldiimidazole in THF is stirred at room temperature for 16 hours. The product is separated off and dried, giving 17.6 g of 4-chloro-3H-imidazo[4,5-c]pyridin-2-ol (“1”).

Workup

  1. customThe product is separated off
  2. customdried

Sources & evidence

ORD record
ord-8e3e6a5471ef47f8aca17ae334117f51
Source dataset
uspto-grants-2010_04
Patent number
US07696224B2

Linked notes

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