1,1'-Carbonyldiimidazole → HCID 178517330, compound
Reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[CH:6][C:7]=1[NH2:8].[C:10](N1C=CN=C1)(N1C=CN=C1)=[O:11]>C1COCC1>[Cl:9][C:3]1[C:2]2[NH:1][C:10]([OH:11])=[N:8][C:7]=2[CH:6]=[CH:5][N:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.1 A solution of 17.23 g of 3,4-diamino-2-chloropyridine and 19.46 g of 1,1′-carbonyldiimidazole in THF is stirred at room temperature for 16 hours. The product is separated off and dried, giving 17.6 g of 4-chloro-3H-imidazo[4,5-c]pyridin-2-ol (“1”).
Workup
- customThe product is separated off
- customdried
Sources & evidence
- ORD record
- ord-8e3e6a5471ef47f8aca17ae334117f51
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07696224B2
Reaction notes
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