4-Hydroxybenzaldehyde → 5-(p-Methoxybenzylidene)-hydantoin

HRID 652566

Reaction equation

HRID 652566 reaction equation
[NH2:1][C@H:2]([C:8]([O-:10])=O)[CH2:3][CH2:4][C:5]([O-])=O.[Na+].[Na+].[CH3:13][O:14][C:15]1[CH:22]=[CH:21]C(C=O)=C[CH:16]=1.[NH2:23]CC(O)=O.OC1C=CC([CH:33]=[O:34])=CC=1>>[CH3:13][O:14][C:15]1[CH:16]=[CH:5][C:4]([CH:3]=[C:2]2[NH:1][C:33](=[O:34])[NH:23][C:8]2=[O:10])=[CH:21][CH:22]=1

Participants

5

Reactant 4

HCID 1264-HydroxybenzaldehydeHCID 750GlycineHCID 312444-MethoxybenzaldehydeHCID 167560Disodium glutamate

Product 1

HCID 947495-(p-Methoxybenzylidene)-hydantoin

Procedure

5-(p-Methoxybenzylidene)-hydantoin was prepared in the same manner as in Example 4, except that 46.8 g (0.25 mol) of sodium L-glutamate.monohydrate and 68.1 g (0.50 mol) of p-methoxybenzaldehyde were used in lieu of glycine and p-hydroxybenzaldehyde, respectively. During the reaction, the pH of the reaction mixture was 9.9 to 9.7.

Workup

  1. customDuring the reaction

Sources & evidence

ORD record
ord-21a593b0f39944088baeaee864758153
Source dataset
uspto-grants-1987_06
Patent number
US04672127

Linked notes

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