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Potassium Phosphate, Dibasic → 3-(S)-hydroxymethyl-4-(R)-tert.-butylsulphonyl-2-azetidinone

HRID 65439
Notes
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Reaction equation

HRID 65439 reaction equation
COC1C=CC(C[N:8]2[C@H:11]([S:12]([C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:14])=[O:13])[C@@H:10]([CH2:19][OH:20])[C:9]2=[O:21])=CC=1.S(OOS([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].P([O-])([O-])(O)=O.[K+].[K+]>C(#N)C.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Fe+2].O.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[OH:20][CH2:19][C@@H:10]1[C@@H:11]([S:12]([C:15]([CH3:17])([CH3:16])[CH3:18])(=[O:14])=[O:13])[NH:8][C:9]1=[O:21]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

8

Reactant 3

HCID 24450Potassium Phosphate, DibasicHCID 62655Sodium PersulfateHCID 186047721-p-methoxybenzyl-3-(S)-hydroxymethyl-4-(R)-tert.-butylsulphonyl-2-azetidinone

Product 1

HCID 186047743-(S)-hydroxymethyl-4-(R)-tert.-butylsulphonyl-2-azetidinone

Reagents, catalysts & solvents 4

HCID 62662
Ferrous sulfate heptahydrate
Catalyst
HCID 165397Cupric acetate monohydrateCatalyst
HCID 962WaterSolvent
HCID 6342AcetonitrileSolvent

Procedure

A solution of 68.3 mg (0.2 mmol) of 1-p-methoxybenzyl-3-(S)-hydroxymethyl-4-(R)-tert.-butylsulphonyl-2-azetidinone in 4 ml of acetonitrile is added to a solution of 428 mg (1.8 mmol) of sodium peroxydisulphate, 174 mg (1 mmol) of dipotassium hydrogen phosphate, 1 mg of iron(II) sulphate heptahydrate and 2 mg of copper(II) acetate hydrate in 4 ml of water. The mixture is stirred for 2 hours under an argon atmosphere at a bath temperature of 65°. The resulting mixture is then concentrated to half its volume under reduced pressure and extracted with ethyl acetate. The extract is triturated with methylene chloride and ether and the pure title compound is obtained.

Workup

  1. concentrationThe resulting mixture is then concentrated to half its volume under reduced pressure
  2. extractionextracted with ethyl acetate
  3. customThe extract is triturated with methylene chloride and ether

Sources & evidence

ORD record
ord-139ed6457cd64e2e9fcb010d4805aeea
Source dataset
uspto-grants-1986_09
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04614614

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes