Dimethylformamide → 2-(Chloromethyl)-1-methyl-4-nitrobenzene

Reaction equation

[CH3:1][c:2]1[c:3]([CH2:4][NH:5][C:6](=[O:7])[CH3:8])[cH:9][c:10]([N+:13](=[O:14])[O-:15])[cH:11][cH:12]1.[CH3:21][N:22]([CH3:23])[CH:24]=[O:25].[P:16]([Cl:17])([Cl:18])([Cl:19])=[O:20].[c:26]1([CH3:27])[c:28]([CH3:29])[cH:30][cH:31][cH:32][cH:33]1>>[CH3:1][c:2]1[c:3]([CH2:4][Cl:18])[cH:9][c:10]([N+:13](=[O:14])[O-:15])[cH:11][cH:12]1

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 7237O-Xylene

HCID 24813Phosphorus oxychloride

HCID 13115425N-(2-methyl-5-nitrobenzyl)acetamide

Product 1

HCID 1879522-(Chloromethyl)-1-methyl-4-nitrobenzene

Sources & evidence

ORD record: ord-df8fec3a2d934084aedebaec4a5b642d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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