1,1-Dichloroethane → 1-Oxa-8-aza-spiro[4.5]decane-8-carboxylic acid (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-amide

HRID 684712

Reaction equation

HRID 684712 reaction equation
[CH:45]([N:46]([CH2:47][CH3:48])[CH:49]([CH3:50])[CH3:51])([CH3:52])[CH3:53].[Cl:54][CH:55]([Cl:56])[CH3:57].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34].[O:35]1[CH2:36][CH2:37][CH2:38][C:39]12[CH2:40][CH2:41][NH:42][CH2:43][CH2:44]2.[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1.[c:1]1([O:2][C:8]([NH:9][c:10]2[s:11][c:12]3[c:13]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)[n:14][cH:15][c:16]([O:19][CH3:20])[c:17]3[n:18]2)=[O:27])[cH:3][cH:4][cH:5][cH:6][cH:7]1>>[C:8]([NH:9][c:10]1[s:11][c:12]2[c:13]([N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)[n:14][cH:15][c:16]([O:19][CH3:20])[c:17]2[n:18]1)(=[O:27])[N:42]1[CH2:41][CH2:40][C:39]2([O:35][CH2:36][CH2:37][CH2:38]2)[CH2:44][CH2:43]1

Participants

7

Reactant 6

HCID 63651,1-DichloroethaneHCID 6422Trifluoroacetic acidHCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 219349821-Oxa-8-azaspiro(4.5)decaneHCID 86597258(7-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester

Product 1

HCID 865972741-Oxa-8-aza-spiro[4.5]decane-8-carboxylic acid (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-amide

Sources & evidence

ORD record
ord-9002d5bf685243b79a972bbc9ec2cba7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Linked notes

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