Chloride → N-tert.-butyl-6-chloro-4-p-fluoro-phenyl-nicotinamide
Reaction equation
[C:10]([CH3:11])([CH3:12])([CH3:13])[NH:14][C:15]([c:16]1[cH:17][n:18][c:19]([Cl:22])[cH:20][cH:21]1)=[O:23].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:24][OH:25].[Cl-:1].[Cl:26][C:27]1=[C:38]([Cl:39])[C:36](=[O:37])[C:33]([C:34]#[N:35])=[C:30]([C:31]#[N:32])[C:28]1=[O:29].[F:2][c:3]1[cH:4][cH:5][c:6]([Mg+:9])[cH:7][cH:8]1>>[F:2][c:3]1[cH:4][cH:5][c:6](-[c:21]2[c:16]([C:15]([NH:14][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:23])[cH:17][n:18][c:19]([Cl:22])[cH:20]2)[cH:7][cH:8]1Participants
7
Sources & evidence
- ORD record
- ord-ee5aedb6612e40a9a332295d3636b668
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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