1,3-Propanediamine → 4-Iodobiphenyl

HRID 722830

Reaction equation

HRID 722830 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[I-:14].[Na+].C(N)CCN>C(O)CCCC>[I:14][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 5238Sodium IodideHCID 71014-Bromobiphenyl2×

Product 1

HCID 153224-Iodobiphenyl

Reagents, catalysts & solvents 1

HCID 62761-PentanolSolvent

Procedure

30 g of 4-bromobiphenyl is dissolved in 40 mL of n-pentanol. 2 equivalents of sodium iodide and 10 mole % of 1,3-propanediamine are added to the 4-bromobiphenyl solution. The reaction mixture is refluxed at 130° C. for sixteen (16) hours to produce 4-iodobiphenyl, as shown in reaction scheme (5).

Sources & evidence

ORD record
ord-e26975268c1443fcb894981069a57230
Source dataset
uspto-grants-2006_11
Patent number
US07138555B2

Linked notes

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