Benzaldehyde → HCID 178419021, compound

HRID 7511

Reaction equation

HRID 7511 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH:12]1([N+:18]#[C-:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.[CH:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[C:28]([Cl:31])(=[O:30])[CH3:29]>Cl(O)(=O)(=O)=O>[Cl-:31].[C:28]([N+:1]1[C:20]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[C:19]([NH:18][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH:10]=[CH:11][C:2]=12)(=[O:30])[CH3:29]

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 6367Acetyl chlorideHCID 113792-AminoquinolineHCID 79129Cyclohexyl isocyanide

Product 1

HCID 178419021HCID 178419021, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 5 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-quinoline (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

Sources & evidence

ORD record
ord-779ad3fbf89541cb9a272f3ad6e35d8a
Source dataset
uspto-grants-2006_08
Patent number
US07087607B2

Linked notes

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