Benzaldehyde → HCID 178418783, compound

HRID 7516

Reaction equation

HRID 7516 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]([N+:12]#[C-:13])([CH3:11])([CH3:10])[CH3:9].[CH:14](=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH:22]1([C:28]([Cl:30])=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>Cl(O)(=O)(=O)=O>[Cl-:30].[C:8]([N:12]([C:28]([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:29])[C:13]1[N:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]2=[N+:1]([C:14]([CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:21])[C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:11])([CH3:10])[CH3:9]

Participants

6

Reactant 4

HCID 240BenzaldehydeHCID 104392-AminopyridineHCID 23577Tert-Butyl isocyanideHCID 75938Cyclohexanecarbonyl chloride

Product 1

HCID 178418783HCID 178418783, compound

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Example 10 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-pyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) tert.-butylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) benzaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process steps b) to d) by reacting the resultant reaction product with 0.4 mmol cyclohexylcarboxylic acid chloride.

Sources & evidence

ORD record
ord-cb1d1f9e1bc94670a80cb99ed22a0e19
Source dataset
uspto-grants-2006_08
Patent number
US07087607B2

Linked notes

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