2-Chloroethanol → 2-(Pyridin-3-yloxy)ethan-1-ol

HRID 75474Notes

Reaction equation

HRID 75474 reaction equation
[OH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.Cl[CH2:9][CH2:10][OH:11].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:1][CH2:9][CH2:10][OH:11])[CH:3]=1

Participants

5

Reactant 3

HCID 342-ChloroethanolHCID 79713-HydroxypyridineHCID 11430Potassium Carbonate

Product 1

HCID 219089972-(Pyridin-3-yloxy)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The yield of the title compound according to D1, starting from 3-hydroxypyridine, 2-chloroethanol and K2CO3 in DMF was 19%. The title compound has also been prepared according to EP 0 286 242 A2 starting from methyl [(3-pyridinyl)oxy]acetate.

Sources & evidence

ORD record
ord-b440f9e1831244a0b541a4df6290b27d
Source dataset
uspto-grants-2014_09
Patent number
US08835439B2

Reaction notes

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