Tetrahydrofuran → 3,3-dimethyl-N-(3-{[4-(trifluoromethoxy)phenyl]ethynyl}pyrazolo[1,5-a]pyrimidin-2-yl)butanamide

HRID 811302

Reaction equation

HRID 811302 reaction equation
[C:49]([PH:50]([Pd:51][PH:52]([C:53]([CH3:54])([CH3:55])[CH3:56])([C:57]([CH3:58])([CH3:59])[CH3:60])[C:61]([CH3:62])([CH3:63])[CH3:64])([C:65]([CH3:66])([CH3:67])[CH3:68])[C:69]([CH3:70])([CH3:71])[CH3:72])([CH3:73])([CH3:74])[CH3:75].[C:8](#[CH:9])[c:10]1[cH:11][cH:12][c:13]([O:16][C:17]([F:18])([F:19])[F:20])[cH:14][cH:15]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:21][C:22]([CH2:23][C:24](=[O:25])[NH:26][c:27]1[n:28][n:29]2[c:30]([n:31][cH:32][cH:33][cH:34]2)[c:35]1-[c:36]1[cH:37][n:38][cH:39][cH:40][cH:41]1)([CH3:42])[CH3:43].[Cu:76][I:77].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[C:8](#[C:9][c:35]1[c:27]([NH:26][C:24]([CH2:23][C:22]([CH3:21])([CH3:42])[CH3:43])=[O:25])[n:28][n:29]2[c:30]1[n:31][cH:32][cH:33][cH:34]2)[c:10]1[cH:11][cH:12][c:13]([O:16][C:17]([F:18])([F:19])[F:20])[cH:14][cH:15]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27784941-Ethynyl-4-(trifluoromethoxy)benzeneHCID 68751160HCID 68751160, compoundHCID 178454917HCID 178454917, compound

Product 1

HCID 687489723,3-dimethyl-N-(3-{[4-(trifluoromethoxy)phenyl]ethynyl}pyrazolo[1,5-a]pyrimidin-2-yl)butanamide

Sources & evidence

ORD record
ord-10dd6c2667d0455d816a97862210384e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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