Hydrochloric Acid → {2-[3-(7-Methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-ureido]-ethyl}-carbamic acid tert-butyl ester

HRID 831309Notes

Reaction equation

HRID 831309 reaction equation
[C:31]([CH3:32])([CH3:33])([CH3:34])[O:35][C:36](=[O:37])[NH:38][CH2:39][CH2:40][NH:41][C:42]([OH:43])=[O:44].[CH3:1][O:2][c:3]1[c:4]2[c:5]([n:6][cH:7][n:8]1)[s:9][c:10]([NH2:12])[n:11]2.[Cl:19][C:20]([Cl:21])([O:22][C:23](=[O:24])[O:25][C:26]([Cl:27])([Cl:28])[Cl:29])[Cl:30].[ClH:45].[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1.[cH:13]1[cH:14][cH:15][n:16][cH:17][cH:18]1>>[CH3:1][O:2][c:3]1[c:4]2[c:5]([n:6][cH:7][n:8]1)[s:9][c:10]([NH:12][C:42]([NH:41][CH2:40][CH2:39][NH:38][C:36]([O:35][C:31]([CH3:32])([CH3:33])[CH3:34])=[O:37])=[O:43])[n:11]2

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 8028TetrahydrofuranHCID 94429TriphosgeneHCID 22242930(2-((Tert-butoxycarbonyl)amino)ethyl)carbamic acidHCID 574765977-Methoxy-[1,3]thiazolo[5,4-d]pyrimidin-2-amine

Product 1

HCID 59011968{2-[3-(7-Methoxy-thiazolo[5,4-d]pyrimidin-2-yl)-ureido]-ethyl}-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-2cc53a5e66a446f5ab8096debcdcc9b3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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