Hydrochloric Acid → 3-(3-Iodophenyl)imidazolidine-2,4-dione
Reaction equation
[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH:11][CH2:12][C:13]([O:15]CC)=O)=[O:10])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].Cl>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:15])[CH2:12][NH:11][C:9]2=[O:10])[CH:5]=[CH:6][CH:7]=1Participants
5
Procedure
A solution of ethyl N-{[(3-iodophenyl)amino]carbonyl}glycinate (9.42 g) in DMF (60 ml) was treated with sodium hydride (60% oil dispersion, 1.2 g) at 20° C. After 2 h the reaction mixture was treated with aqueous 2M HCl (200 ml) and stirred overnight. The solid was collected by filtration, washed with water and dried to give the title compound (6.9 g) LCMS RT=2.45 min.
Workup
- filtrationThe solid was collected by filtration
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-64023520ea564a86a19be31abc8c1cae
- Source dataset
- uspto-grants-2006_12
- Patent number
- US07144908B2
Reaction notes
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