Ethyl Bromide → 2-Ethoxybenzonitrile
Reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
25 g (210 mmol) of 2-hydroxylbenzonitrile are heated, together with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide, in 500 ml of acetone under reflux overnight. The solid is filtered off, the solvent is removed in vacuo and the residue is distilled in vacuo. 30.0 g (97%) of a colorless liquid are obtained.
Workup
- temperatureunder reflux overnight
- filtrationThe solid is filtered off
- customthe solvent is removed in vacuo
- distillationthe residue is distilled in vacuo
Sources & evidence
- ORD record
- ord-ce3fd0b48b39417c9f1ac902d61127bf
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07091203B2
Reaction notes
Loading…