Sodium hydride → HCID 86696429, compound
Reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[N:12]2[N:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]2=[N:10][CH:9]=1)=[O:6].[H-].[Na+]>CN(C=O)C.CCOC(C)=O>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]2[N:12]([C:8]([N:7]3[CH2:2][CH2:3][CH2:4][C:5]3=[O:6])=[CH:9][N:10]=2)[N:13]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To 1.0 g of 4-bromo-N-(6-chloroimidazo[1,2-b]pyridazin-3-yl)butanamide (3.15 mmol) dissolved in 39 mL DMF was added NaH (189 mg, 4.72 mmol), and stirred at rt for 0.5 hr. Dilute with 50 mL EtOAc and separate the organic layer. Wash twice with water, once with brine and dry over MgSO4. Concentrate to obtain the product 0.49 g (66%). No purification was needed.
Workup
- customseparate the organic layer
- washWash twice with water, once with brine
- dry with materialdry over MgSO4
- concentrationConcentrate
Sources & evidence
- ORD record
- ord-ef82852c93bb478197d76aa645b46d71
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08969565B2
Reaction notes
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