CS(C)=O.Cl.[NH2:6][OH:7].C(N(CC)CC)C.[O:15]=[S:16]1(=[O:36])[C:22]2[CH:23]=[C:24]([O:27][C:28]3[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=3)[C:31]#[N:32])[CH:25]=[CH:26][C:21]=2[NH:20][CH2:19][CH2:18][NH:17]1>C(OCC)C.ClCCl.O.C1COCC1>[O:36]=[S:16]1(=[O:15])[C:22]2[CH:23]=[C:24]([O:27][C:28]3[CH:29]=[C:30]([C:31](=[N:6][OH:7])[NH2:32])[CH:33]=[CH:34][CH:35]=3)[CH:25]=[CH:26][C:21]=2[NH:20][CH2:19][CH2:18][NH:17]1
To 750 μl of DMSO there are added hydroxylamine hydrochloride (1.90 mmol) and then triethylamine (1.90 mmol). An abundant white precipitate is formed, which is diluted by adding 3 ml of THF and stirring is carried out for 25 minutes at ambient temperature. The THF is evaporated off under reduced pressure and the suspension is filtered. The product of Example 6 (0.317 mmol) is added to the filtrate and the solution is stirred overnight at ambient temperature. After adding water to the reaction mixture, a gum forms which is made solid by adding dichloromethane and ethyl ether. The solid is filtered off and rinsed with water and ethyl ether to yield the title product.
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