Potassium Cation → 2-[7-(2,2-Dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-2,3-dihydro-isoindol-1-one

HRID 88838

Reaction equation

HRID 88838 reaction equation
[Br:1][c:2]1[n:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[cH:9][c:10]2[C:11]([C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16].[C:25]1(=[O:34])[NH:26][CH2:27][c:28]2[cH:29][cH:30][cH:31][cH:32][c:33]21.[C:35](=[O:36])([O-:37])[O-:38].[CH3:41][N:42]([CH3:43])[CH2:44][CH2:45][NH2:46].[CH3:47][CH2:48][O:49][C:50](=[O:51])[CH3:52].[CH3:56][c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1.[Cu:53]([I:54])[I:55].[K+:39].[K+:40]>>[c:2]1([N:26]2[C:25](=[O:34])[c:33]3[c:28]([cH:29][cH:30][cH:31][cH:32]3)[CH2:27]2)[n:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[cH:9][c:10]2[C:11]([C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16]

Participants

9

Reactant 8

HCID 813Potassium Cation2×HCID 1140TolueneHCID 8857Ethyl AcetateHCID 10199PhthalimidineHCID 19660Carbonate IonHCID 66053N,N-DimethylethylenediamineHCID 83717Copper iodideHCID 578292211-(2-bromo-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-yl)-2,2-dimethylpropane-1-one

Product 1

HCID 578296432-[7-(2,2-Dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-2,3-dihydro-isoindol-1-one

Sources & evidence

ORD record
ord-d415d867a759445c9b1357fc6b443b44
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

Loading…