Dichloromethane → N-[3-(2-Chloro-pyrimidin-4-ylethenyl)-phenyl]-2,2,2-trifluoro-acetamide

Reaction equation

[C:9](#[CH:10])[c:11]1[cH:12][c:13]([NH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[O:23])[cH:14][cH:15][cH:16]1.[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([Cl:8])[n:7]1.[Cl:29][CH2:30][Cl:31].[Cu:32][I:33]>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([CH:10]=[CH:9][c:11]2[cH:12][c:13]([NH:17][C:18]([C:19]([F:20])([F:21])[F:22])=[O:23])[cH:14][cH:15][cH:16]2)[n:7]1

Participants

Reactant 5

HCID 6344Dichloromethane

HCID 8028Tetrahydrofuran

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 775312,4-Dichloropyrimidine

HCID 59513885N-(3-ethynylphenyl)-2,2,2-trifluoroacetamide

Product 1

HCID 86631082N-[3-(2-Chloro-pyrimidin-4-ylethenyl)-phenyl]-2,2,2-trifluoro-acetamide

Sources & evidence

ORD record: ord-6d9aec16e2b24abd8814ea617ad846fc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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