Chloride → Tert-butyl 2-(2,5-difluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

HRID 92324

Reaction equation

HRID 92324 reaction equation
[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:32][CH2:33][O:34][C:35](=[O:36])[CH3:37].[Cl-:1].[Cl-:24].[Cl-:26].[F:2][c:3]1[c:4]([Mg+:10])[cH:5][c:6]([F:9])[cH:7][cH:8]1.[Mg+2:25].[O:11]=[C:12]1[N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15][CH2:16]1>>[F:2][c:3]1[c:4]([C:12]2([OH:11])[N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15][CH2:16]2)[cH:5][c:6]([F:9])[cH:7][cH:8]1

Participants

7

Reactant 6

HCID 312Chloride3×HCID 888Magnesium CationHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 3790001-Pyrrolidinecarboxylic acid, 2-oxo-, 1,1-dimethylethyl esterHCID 178505814HCID 178505814, compound

Product 1

HCID 58335834Tert-butyl 2-(2,5-difluorophenyl)-2-hydroxypyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-a13903fd12fb44af85fd6e9aae11d7ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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