Dimethylformamide → cis-N-[1-[3-(4-Fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-4-amino-5-chloro-2-((S)-1-methyl-2-butynyl)oxybenzamide

Reaction equation

[CH3:1][O:2][C@H:3]1[C@@H:8]([NH:9][C:10](=[O:25])[C:11]2[CH:16]=[C:15]([Cl:17])[C:14]([NH2:18])=[CH:13][C:12]=2[O:19][C@@H:20]([CH3:24])[C:21]#[C:22][CH3:23])[CH2:7][CH2:6][NH:5][CH2:4]1.[F:26][C:27]1[CH:37]=[CH:36][C:30]([O:31][CH2:32][CH2:33][CH2:34]Br)=[CH:29][CH:28]=1.C(N(CC)CC)C.CN(C=O)C>C(OCC)(=O)C>[F:26][C:27]1[CH:37]=[CH:36][C:30]([O:31][CH2:32][CH2:33][CH2:34][N:5]2[CH2:6][CH2:7][C@H:8]([NH:9][C:10](=[O:25])[C:11]3[CH:16]=[C:15]([Cl:17])[C:14]([NH2:18])=[CH:13][C:12]=3[O:19][C@@H:20]([CH3:24])[C:21]#[C:22][CH3:23])[C@H:3]([O:2][CH3:1])[CH2:4]2)=[CH:29][CH:28]=1