Triethylamine → 3-[3-(8-Isopropyl-2,2,4,4-tetramethyl-chroman-6-ylethynyl)phenyl]-acrylic acid ethyl ester

HRID 945221

Reaction equation

HRID 945221 reaction equation
[C:1](#[CH:2])[c:3]1[cH:4][c:5]2[c:10]([c:11]([CH:13]([CH3:14])[CH3:15])[cH:12]1)[O:9][C:8]([CH3:16])([CH3:17])[CH2:7][C:6]2([CH3:18])[CH3:19].[CH2:20]([CH3:21])[O:22][C:23]([CH:24]=[CH:25][c:26]1[cH:27][c:28]([I:32])[cH:29][cH:30][cH:31]1)=[O:33].[CH2:77]([N:78]([CH2:79][CH3:80])[CH2:81][CH3:82])[CH3:83].[Cu:34][I:35].[Pd:36]([Cl:37])[Cl:38].[c:39]1([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[cH:53][cH:54][cH:55][cH:56][cH:57]1.[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[C:1](#[C:2][c:28]1[cH:27][c:26]([CH:25]=[CH:24][C:23]([O:22][CH2:20][CH3:21])=[O:33])[cH:31][cH:30][cH:29]1)[c:3]1[cH:4][c:5]2[c:10]([c:11]([CH:13]([CH3:14])[CH3:15])[cH:12]1)[O:9][C:8]([CH3:16])([CH3:17])[CH2:7][C:6]2([CH3:18])[CH3:19]

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 211072306-Ethynyl-8-isopropyl-2,2,4,4-tetramethylchromanHCID 545009022-Propenoic acid, 3-(3-iodophenyl)-, ethyl ester

Product 1

HCID 690717073-[3-(8-Isopropyl-2,2,4,4-tetramethyl-chroman-6-ylethynyl)phenyl]-acrylic acid ethyl ester

Sources & evidence

ORD record
ord-95d70d72aef744c38bbf5e573d089ace
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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