→ Ethyl 1,4-dihydro-2-hydroxy-6-methyl-4-phenyl-5-pyrimidinecarboxylate

HRID 962302

Reaction equation

HRID 962302 reaction equation
CC(=O)O.CCO.CCOC(=O)CC(C)=O.NC(N)=O.O.O=Cc1ccccc1.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.O=S(=O)([O-])C(F)(F)F.[Yb+3]>>CCOC(=O)C1=C(C)NC(=O)NC1c1ccccc1

Participants

7

Reactant 0

No Reactant data yet.

Product 1

HCID 220272Ethyl 1,4-dihydro-2-hydroxy-6-methyl-4-phenyl-5-pyrimidinecarboxylateYield 92%

Reagents, catalysts & solvents 6

HCID 176Acetic AcidOtherHCID 240BenzaldehydeOtherHCID 702EthanolOtherHCID 1176UreaOtherHCID 8868Ethyl AcetoacetateOtherHCID 45075687Ytterbium(3+) trifluoromethanesulfonate--water (1/3/1)Other

Conditions

Temperature
120 °C

Workup

  1. waitNo procedure recorded
  2. filtrationKeep solid
  3. washNo procedure recorded
  4. dry in vacuumNo procedure recorded

Sources & evidence

ORD record
ord-fdfacfa5c1b143ed8ad19a85e3ee5a34
Source dataset
Microwave-assisted Biginelli Condensation Dataset
Original link
View source

Linked notes

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