Tert-Butyl isocyanide → (2-Anthracen-9-yl-imidazo[1,2-a]pyrazin-3-yl)-tert-butyl-amine

HRID 989004

Reaction equation

HRID 989004 reaction equation
[NH2:1][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[C:8]([N+:12]#[C-:13])([CH3:11])([CH3:10])[CH3:9].[CH:14]1[C:27]2[C:18](=[CH:19][C:20]3[C:25]([C:26]=2[CH:28]=O)=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:17]=[CH:16][CH:15]=1>Cl(O)(=O)(=O)=O>[CH:24]1[C:25]2[C:20](=[CH:19][C:18]3[C:27]([C:26]=2[C:28]2[N:1]=[C:2]4[CH:7]=[N:6][CH:5]=[CH:4][N:3]4[C:13]=2[NH:12][C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 23577Tert-Butyl isocyanideHCID 695049-AnthracenecarboxaldehydeHCID 78747Aminopyrazine

Product 1

HCID 17937207(2-Anthracen-9-yl-imidazo[1,2-a]pyrazin-3-yl)-tert-butyl-amine

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (30) was prepared in accordance with general instructions 1 from 1.0 ml 2-aminopyrazine solution (0.1 M, MC), 0.575 ml tert-butyl isocyanide solution (0.2 M, MC), 0.500 ml anthracene-9-carbaldehyde solution (0.3 M, MC), and 10 μl perchloric acid (w=20%). Calculated mass 366.5; found mass 367.3 (ESI-MS)

Sources & evidence

ORD record
ord-37a8b151357044feb540d0a6fe07f897
Source dataset
uspto-grants-2003_10
Patent number
US06638933B2

Linked notes

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