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Estradiol → Estradiol methyltestosterone

HRID 991390
Notes
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Reaction equation

HRID 991390 reaction equation
[CH3:1][C@@:2]12[C@H:12]3[CH2:13][CH2:14][C@:15]4([CH3:22])[C@:19]([OH:21])([CH3:20])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2.C[C@@]12[C@@H](O)CC[C@H]1[C@H]1[C@@H](C3C=CC(O)=CC=3CC1)CC2.C([O-])(=O)C=C.CC(O)COC(CO)C.C(O)CCCCCCC/C=C\CCCCCCCC>C(OCC)(=O)C.CCCCCC.C(O)(C)C>[CH3:22][C@@:15]12[C@@H:19]([OH:21])[CH2:18][CH2:17][C@H:16]1[C@H:11]1[C@@H:12]([C:2]3[CH:3]=[CH:4][C:5]([OH:6])=[CH:7][C:8]=3[CH2:9][CH2:10]1)[CH2:13][CH2:14]2.[CH3:1][C@@:2]12[C@H:12]3[CH2:13][CH2:14][C@:15]4([CH3:22])[C@:19]([OH:21])([CH3:20])[CH2:18][CH2:17][C@H:16]4[C@@H:11]3[CH2:10][CH2:9][C:8]1=[CH:7][C:5](=[O:6])[CH2:4][CH2:3]2
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

10

Reactant 6

HCID 5757EstradiolHCID 6010MethyltestosteroneHCID 25188AcrylateHCID 328812-(2-Hydroxypropoxy)-1-propanolHCID 5284499Oleyl AlcoholHCID 178527255HCID 178527255, compound

Product 1

HCID 9829635
Estradiol methyltestosterone

Reagents, catalysts & solvents 3

HCID 3776IsopropanolSolventHCID 8058HexaneSolventHCID 8857Ethyl AcetateSolvent3×

Procedure

An estradiol/methyltestosterone pressure-sensitive adhesive mixture was prepared by combining 4.0 parts of methyltestosterone and 1.1 parts of estradiol in a solution of 42.3 parts of CAB-381-0.1 with 38.0 parts each of isopropyl alcohol and ethyl acetate. Then 76.5 parts of a polysiloxane adhesive (BIO-PSA® Q7-4502, a silicone in ethyl acetate; Dow Corning Corporation, Medical Products, Midland, Mich.), 48.8 parts of a polyacrylate adhesive (DURO-TAK® 87-2510, an acrylate copolymer in ethyl acetate and hexane; National Starch and Chemical Corporation, Bridgewater, N.J.), 8.0 parts of dipropylene glycol and 6.0 parts of oleyl alcohol were added and thoroughly mixed in an appropriate container until the mixture was completely homogeneous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of volatile solvents) as shown below.

Workup

  1. additionthoroughly mixed in an appropriate container until the mixture
  2. concentrationthe ingredient concentrations
  3. customon a dry weight percent basis (i.e., after evaporation of volatile solvents)

Sources & evidence

ORD record
ord-84160a0d70d14e1087576ca7a0ef96f3
Source dataset
uspto-grants-2002_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06465004B1

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes