Hydrochloric Acid → N-{2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-(4,5-dimethyl-1,3-thiazol-2-yl)urea

HRID 99850

Reaction equation

HRID 99850 reaction equation
[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[CH:52]([Cl:53])([Cl:54])[Cl:55].[Cl:1][c:2]1[c:3]([NH2:4])[cH:5][cH:6][c:7]([O:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:22][CH3:23])[c:17]([O:20][CH3:21])[cH:18][c:19]23)[cH:8]1.[Cl:31][C:32]([Cl:33])([O:34][C:35]([O:36][C:37]([Cl:38])([Cl:39])[Cl:40])=[O:41])[Cl:42].[ClH:43].[NH2:44][c:45]1[s:46][c:47]([CH3:51])[c:48]([CH3:50])[n:49]1.[OH2:56]>>[Cl:1][c:2]1[c:3]([NH:4][C:35](=[O:41])[NH:44][c:45]2[s:46][c:47]([CH3:51])[c:48]([CH3:50])[n:49]2)[cH:5][cH:6][c:7]([O:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:22][CH3:23])[c:17]([O:20][CH3:21])[cH:18][c:19]23)[cH:8]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 962WaterHCID 6212ChloroformHCID 8471TriethylamineHCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 94429TriphosgeneHCID 218898992-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)aniline

Product 1

HCID 22637155N-{2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-(4,5-dimethyl-1,3-thiazol-2-yl)urea

Sources & evidence

ORD record
ord-fbbd0a7275ae4f9d8e58ca1aa3ee9649
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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