硫酸テトラデシルナトリウム

Danger

H302 (70.5%): Harmful if swallowed [Warning Acute toxicity, oral]；H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]；H312 (17.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H314 (69.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (29.5%): Causes skin irritation [Warning Skin corrosion/irritation]；H318 (29.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P260, P262, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P332+P317, P361+P364, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 78 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: 4-Undecanol, 7-ethyl-2-methyl-, hydrogen sulfate, sodium salt

4-Undecanol, 7-ethyl-2-methyl-, hydrogen sulfate, sodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

A mild eye and severe skin irritant; Causes somnolence, other gastrointestinal changes, and hematuria in oral lethal-dose studies of rats and guinea pigs; [RTECS] 26-28% Aqueous solution: Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract; Harmful by ingestion; Toxic by skin absorption; [Sigma-Aldrich MSDS]

Acute Tox. 4 (70.5%)；Acute Tox. 3 (50%)；Acute Tox. 4 (17.9%)；Skin Corr. 1B (69.2%)；Skin Irrit. 2 (29.5%)；Eye Dam. 1 (29.5%)

Hazardous to the aquatic environment (Acute) - Category 2；Hazardous to the aquatic environment (Long-term) - Category 2

Chemical: 4-Undecanol, 7-ethyl-2-methyl-, hydrogen sulfate, sodium salt

4-Undecanol, 7-ethyl-2-methyl-, hydrogen sulfate, sodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

C - Cardiovascular system；C05 - Vasoprotectives；C05B - Antivaricose therapy；C05BB - Sclerosing agents for local injection；C05BB04 - Sodium tetradecyl sulfate

QC - Cardiovascular system；QC05 - Vasoprotectives；QC05B - Antivaricose therapy；QC05BB - Sclerosing agents for local injection；QC05BB04 - Sodium tetradecyl sulfate

Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.

Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.