Bifonazole → HCID 178521215、化合物

HRID 1389058

反応式

HRID 1389058 の反応式
[C:1]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:6]=[CH:5][C:4]([CH:7]([N:14]2[CH:18]=[CH:17][N:16]=[CH:15]2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.[Br:25][CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:28]>C(#N)C>[Br-:25].[C:1]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:2]=[CH:3][C:4]([CH:7]([N+:14]2[CH:18]=[CH:17][N:16]([CH2:26][C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:28])[CH:15]=2)[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 2378BifonazoleHCID 6259Phenacyl bromide

生成物 1

HCID 178521215HCID 178521215、化合物収率 82.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

15.1 g (0.05 mol) of 1-[α-(4-biphenylyl)-benzyl]-imidazole and 10 g (0.05 mol) of ω-bromoacetophenone are suspended in 500 ml of acetonitrile. After stirring for 15 hours at room temperature, the resulting clear solution is concentrated to about 50 ml. The crystals which hereupon separate out are filtered off and dried. 21 g (82.5% of theory) of 1-[α-(4-biphenylyl)-benzyl]-3-phenacylimidazolium bromide of melting point 210° C. (with decomposition) are obtained.

後処理

  1. concentrationthe resulting clear solution is concentrated to about 50 ml
  2. customThe crystals which hereupon separate out
  3. filtrationare filtered off
  4. customdried

出典と根拠

ORDレコード
ord-49fe7d9561af495989e10a8de316869c
出典データセット
uspto-grants-1981_01
特許番号
US04243670

関連ノート

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