1,1,1,2,3,3-ヘキサフルオロ-2-プロペン

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch or walk through spilled material.

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

General First Aid:

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

· Wear positive pressure self-contained breathing apparatus (SCBA).

Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:

Immediate precautionary measure

Immediate precautionary measure

40 [ppm]

91 [ppm]

480 [ppm]

· Use extinguishing agent suitable for type of surrounding fire.

· Use extinguishing agent suitable for type of surrounding fire.

ERPG-1: 10 ppm - one hour exposure limit: 1 = mild transient health effects or objectionable odor [AIHA]

Emergency Response Planning Guidelines (ERPG): ERPG(1) 10 ppm (no more than mild, transient effects) for up to 1 hr exposure; ERPG(2) 50 ppm (without serious, adverse effects) for up to 1 hr exposure; ERPG(3) 500 ppm (not life threatening) up to 1 hr exposure.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to have moderate mobility in soil(SRC). Volatilization of hexafluoropropene is expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Hexafluoropropene is expected to rapidly volatilize from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg(SRC), determined from a fragment constant method(4). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 470(SRC), determined from a structure estimation method(2), indicates that hexafluoropropene is expected to adsorb to suspended solids and sediment in water(SRC). Hexafluoropropene is expected to volatilize rapidly from water surfaces(3,SRC) based on an estimated Henry's Law constant of 5.34 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Estimated half-lives for a model river and model lake are 4 and 116 hours, respectively(3,SRC). According to a classification scheme(5), an estimated BCF value of 24(3,SRC), from an estimated log Kow of 2.12(6,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Highly chlorinated/fluorinated compounds are not expected to biodegrade rapidly(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexafluoropropene, which has a vapor pressure of 4.9X10+3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexafluoropropene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone molecules(SRC); the half-lives for these reactions in air are estimated to be about 21(3,SRC) and 95(4,SRC) days, respectively.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for hexafluoropropene can be estimated to be about 470(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that hexafluoropropene is expected to have moderate mobility in soil(SRC).

The ability of hexafluoropropene (HFP) to cause aberrations in Chinese hamster ovary (CHO) cells in vitro was evaluated in the presence and absence of rat liver S9 metabolic activation. Based on preliminary toxicity tests, nonactivated cultures were treated with 0, 0.01, 0.02, 0.10, 0.17, 0.29, 0.37, 0.43 or 0.59% HFP and activated cultures were treated with 0, 0.09, 0.17, 0.33, 0.46, 0.55, 0.67, 0.85, 1.40% HFP. Significant increases were observed in numbers of aberrations/cell, percent abnormal cells, and percent cells with >1 aberration relative to controls in nonactivated and activated cultures at the highest four dose levels (0.29% and 0.55% and above, respectively). Positive dose-related trends were observed for all three measurements in both nonactivated and activated cultures.

An estimated BCF value of 24 was calculated for hexafluoropropene(SRC), using an estimated log Kow of 2.12(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for hexafluoropropene is estimated as 5.34 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that hexafluoropropene will volatilize rapidly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 4 hours(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 116 hours(2,SRC). Hexafluoropropene's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces is expected(SRC). Hexafluoropropene is expected to volatilize rapidly from dry soil surfaces based on a vapor pressure of 4.9X10+3 mm Hg at 25 °C(3).

MALE RATS EXPOSED TO AIR CONTAINING SUBLETHAL CONCN OF HEXAFLUOROPROPENE SHOWED INCR IN URINARY FLUORIDE AFTER EXPOSURE. INHALATION ALSO PRODUCED INCR IN URINARY EXCRETION OF POTASSIUM ION (K-+) & CREATININE, & A DIURESIS WHICH PERSISTED FOR 2 WK POST-EXPOSURE. HISTOLOGICALLY, FRANK NECROSIS OF PROXIMAL RENAL TUBULES WERE OBSERVED.

MALE FISCHER-344 RATS WERE SUBJECTED TO 4 HR INHALATION OF HEXAFLUOROPROPENE AT 380-1200 PPM. WITHIN 2 DAYS RATS EXHIBITED DOSE-RELATED PROXIMAL TUBULAR NECROSIS, DIURESIS, INCREASES IN URINARY FLUORIDE, URINARY LACTIC DEHYDROGENASE (LDH) ACTIVITY, SERUM CREATININE & BLOOD UREA NITROGEN. IT PRODUCED NECROSIS OF PARS RECTA & PARS CONVOLUTA PORTIONS OF PROXIMAL TUBULE. AT LOWEST CONCN DIURESIS WAS MOST SENSITIVE INDEX OF TOXICITY MANIFESTING 50% INCR IN WATER INTAKE & 25% DECR IN URINE OSMOLALITY. INCREASES IN URINARY LDH ACTIVITY CORRELATED WITH DEGREE OF PROXIMAL RENAL TUBULAR NECROSIS, WITH GREATER THAN 100-FOLD INCR AT HIGHEST CONCN. ALL CONCN PRODUCED NECROSIS WITHIN 24 HR POSTEXPOSURE, WITH TUBULAR CELL REGENERATION APPARENT WITHIN 4 DAYS.

The rate constant for the vapor-phase reaction of hexafluoropropene with photochemically-produced hydroxyl radicals has been estimated as 7.74X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 21 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). The rate constant for the vapor-phase reaction of hexafluoropropene with ozone has been measured as 7.7X10-20 cu cm/molecule-sec at 25 °C(2). This corresponds to an atmospheric half-life of about 95 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2,SRC). Hexafluoropropene is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(SRC).