Azobisisobutyronitrile → 6-(Bromomethyl)benzo[d]oxazole
反応式
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][O:8][C:4]=2[CH:3]=1.[Br:11]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)Cl>[Br:11][CH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][O:8][C:4]=2[CH:3]=1参加物
5
実験手順
A mixture of 6-methylbenzoxazole (5.0 g; J. T. Gupton, K. F. Correia and B. S. Foster, Synthetic Communications, 1986, 16, 365), N-bromosuccinimide (7.0 g) and azobisisobutyronitrile (0.55 g) in dry chloroform (100 ml) was heated at reflux for 1 hour. The cooled reaction mixture was washed three times with water (40 ml), dried over magnesium sulphate and evaporated. The residual orange coloured viscous solid was triturated twice with pentane (50 ml) affording the title compound (6.20 g) as a buff coloured solid, m.p. 52-56° C.
後処理
- temperaturewas heated
- temperatureat reflux for 1 hour
- customThe cooled reaction mixture
- washwas washed three times with water (40 ml)
- dry with materialdried over magnesium sulphate
- customevaporated
- customwas triturated twice with pentane (50 ml)
出典と根拠
- ORDレコード
- ord-73ba69673ea74b60b537ac0003fae1a0
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06048893
反応ノート
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