Water → 2-(2-Bromo-3-methylphenyl)ethylmethylether
反応式
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][OH:11].[H-].[Na+].[CH3:14]I.O>O1CCCC1.C(O)(=O)C>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][O:11][CH3:14]参加物
7
実験手順
To a stirred solution of 2-(2-bromo-3-methylphenyl)ethanol (1.6 g, 7.4 mmol) in tetrahydrofuran (20 ml) was added sodium hydride (50% in oil) (0.46 g, 9.6 mmol). After stirring the mixture for 15 min methyl iodide (1.6 g, 11.3 mmol) was added and the reaction mixture was stirred for 3 h. at room temperature. Water (0.2 g) was added and then acetic acid (0.2 g). The solvents were evaporated under reduced pressure and purification of the residue by column chromatography on silica gel using methylene chloride as eluent gave 1.5 g (89%) of the desired product as an oil.
後処理
- additionwas added
- customThe solvents were evaporated under reduced pressure and purification of the residue by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-1b1428be00a1446b8e33c33e8efbd0fa
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06790960B2
反応ノート
読み込み中…