Nitric Acid → 6-Methyl-5-nitroquinoline

HRID 1017128

反応式

HRID 1017128 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.S(=O)(=O)(O)O.[N+:17]([O-])([OH:19])=[O:18].[OH-].[Na+]>>[N+:17]([C:3]1[C:2]([CH3:1])=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][CH:7]=[N:8]2)([O-:19])=[O:18]

参加物

5

反応物 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 70596-MethylquinolineHCID 14798Sodium Hydroxide

生成物 1

HCID 900096-Methyl-5-nitroquinoline

実験手順

2.45 mol of 6-methylquinoline were added to 1 l of concentrated sulfuric acid, and 2.94 mol of 65% strength nitric acid were added dropwise at from 0 to 10° C. The mixture was stirred for one hour, poured onto ice, adjusted to pH 2.5 using aqueous sodium hydroxide solution, filtered off with suction, washed with water and dried over magnesium sulfate.

後処理

  1. additionwere added dropwise at from 0 to 10° C
  2. additionpoured onto ice
  3. filtrationfiltered off with suction
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate

出典と根拠

ORDレコード
ord-fba0f63ffa8d41a3a1766704edbaa66d
出典データセット
uspto-grants-2002_11
特許番号
US06479436B1

関連ノート

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