反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3]1.[CH2:10](O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.Cl.C(N=C=NCCCN(C)C)C.ON1C2C=CC=CC=2N=N1.C(=O)(O)[O-].[Na+]>O1CCCC1>[CH2:10]([O:8][C:7]([CH:4]1[CH2:5][CH2:6][C:2](=[O:1])[CH2:3]1)=[O:9])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
7
反応物 5
生成物 1
試薬・触媒・溶媒 1
実験手順
The mixture of 3-oxo-cyclopentanecarboxylic acid (750 mg), of benzyl alcohol (633 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 1 (680 mg), and of 1-hydroxybenzotriazole (350 mg) in 50 ml tetrahydrofuran was stirred overnight. After addition of aq. Sodium bicarbonate (sat. 25 mL), the reaction mixture was extracted with of ethyl acetate (50 ml×2). The organic layer was washed with brine, dried with anhydrous sodium sulfate and concentrated to yield 3-oxo-cyclopentanecarboxylic acid benzyl ester as oil.
後処理
- extractionthe reaction mixture was extracted with of ethyl acetate (50 ml×2)
- washThe organic layer was washed with brine
- dry with materialdried with anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cb7821b47b8d410f88f1bbdc77d3fe7d
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08722896B2
関連ノート
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