Allyl bromide → 2',4',6'-Trihydroxy3'-(2-propenyl)acetophenone

HRID 1030683

反応式

HRID 1030683 の反応式
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([OH:9])[C:3]=1[C:10](=[O:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][CH:21]=[CH2:22]>O1CCCC1>[OH:1][C:2]1[C:7]([CH2:22][CH:21]=[CH2:20])=[C:6]([OH:8])[CH:5]=[C:4]([OH:9])[C:3]=1[C:10](=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 680732',4',6'-Trihydroxyacetophenone

生成物 1

HCID 143680782',4',6'-Trihydroxy3'-(2-propenyl)acetophenone収率 41.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In 15 ml of anhydrous tetrahydrofuran was dissolved 3.0 g of 2',4',6'-trihydroxyacetophenone, and 7.4 g of anhydrous potassium carbonate was added to the solution and the mixture was stirred at room temperature for 30 minutes. Then, 2.5 g of 3-bromo-1-propene was added to the mixture and reaction was carried out at room temperature for 3 hours. After the reaction, the reaction mixture was extracted with 500 ml of diethyl ether, and the solvent was removed from the extract by distillation. The obtained residue was recrystallized from benzene to obtain 1.5 g (yield=41.5%) of 2',4',6'-trihydroxy-3'-(2-propenyl)acetophenone in the form of a colorless prism.

後処理

  1. additionwas added to the solution
  2. waitwas carried out at room temperature for 3 hours
  3. customAfter the reaction
  4. extractionthe reaction mixture was extracted with 500 ml of diethyl ether
  5. customthe solvent was removed from the
  6. extractionextract by distillation
  7. customThe obtained residue was recrystallized from benzene

出典と根拠

ORDレコード
ord-3fabc0dff25e41778d2397b75add0719
出典データセット
uspto-grants-1992_04
特許番号
US05106871

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