Methyl iodide → 4-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid

反応式

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:11])[CH:3]=1.Cl[S:13]([OH:16])(=O)=[O:14].S([O-])([O-])=O.[Na+].[Na+].[CH3:23]I>>[CH3:11][C:4]1[CH:3]=[C:2]([Cl:1])[C:10]([S:13]([CH3:23])(=[O:16])=[O:14])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

反応物 4

HCID 6328Methyl iodide

HCID 24437Sodium Sulfite

HCID 24638Chlorosulfonic acid

HCID 3482694-Chloro-2-methylbenzoic acid

生成物 1

HCID 108244784-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid

実験手順

in stage b) 4-chloro-2-methylbenzoic acid is reacted with chlorosulfonic acid, sodium sulfite and methyl iodide to give 2-methyl-4-chloro-5-methylsulfonylbenzoic acid,

出典と根拠

ORDレコード: ord-d3249eb9edbc4f9091d59312d9755496
出典データセット: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06515143B2

反応ノート

読み込み中…