Formaldehyde → 3-(Hydroxymethyl)-1H-pyrrole-2,5-dione

HRID 10604

反応式

HRID 10604 の反応式
[C:1]1(=[O:7])[NH:5][C:4](=[O:6])[CH:3]=[CH:2]1.[CH2:8]=[O:9].[OH-].[Na+]>>[OH:9][CH2:8][C:2]1[C:1]([NH:5][C:4](=[O:6])[CH:3]=1)=[O:7]

参加物

4

反応物 3

HCID 712FormaldehydeHCID 10935MaleimideHCID 14798Sodium Hydroxide

生成物 1

HCID 219817513-(Hydroxymethyl)-1H-pyrrole-2,5-dione

実験手順

24 Parts of maleimide (manufactured by Aldrich Corporation), 21 parts of 35% HCOH (manufactured by Wako Pure Chemical Industries, Ltd.) and 0.7 parts of a 5% aqueous NaOH solution are placed in a reactor and reacted at 40° C. for 2 hours. As a result, a white crystal of hydroxymethylmaleimide precipitates. This white crystal is filtered under reduced pressure and then dried at normal temperature under vacuum. The crude crystal of hydroxymethylmaleimide obtained in this manner is recrystallized from ethyl acetate to obtain 22 parts of hydroxymethylmaleimide.

後処理

  1. customreacted at 40° C. for 2 hours
  2. customAs a result, a white crystal of hydroxymethylmaleimide precipitates
  3. filtrationThis white crystal is filtered under reduced pressure
  4. customdried at normal temperature under vacuum

出典と根拠

ORDレコード
ord-9a2925c670fe42288d32beb72b10d9f5
出典データセット
uspto-grants-2006_08
特許番号
US07094860B2

関連ノート

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