Furan → HCID 22396537、化合物

HRID 1070382

反応式

HRID 1070382 の反応式
[CH:1]12[O:10][CH:7]([CH2:8][CH2:9]1)[CH:6]1[CH:2]2[C:3](=[O:12])[NH:4][C:5]1=[O:11].C1(=O)[NH:17][C:16](=O)[CH:15]=C1.O1C=CC=C1.BrCC#N>CC(C)=O.CN(C=O)C>[O:12]=[C:3]1[N:4]([CH2:15][C:16]#[N:17])[C:5](=[O:11])[CH:6]2[CH:2]1[CH:1]1[O:10][CH:7]2[CH2:8][CH2:9]1

参加物

7

反応物 4

HCID 8029FuranHCID 10935MaleimideHCID 11534BromoacetonitrileHCID 23972710-Oxa-4-azatricyclo(5.2.1.02,6)decane-3,5-dione

生成物 1

HCID 22396537HCID 22396537、化合物

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6228Dimethylformamide溶媒

実験手順

Synthesis took place in analogy to Example VI a from 10-oxa-4-azatricyclo[5.2.1.02,6]decane-3,5-dione (obtainable from maleimide and furan from Diels-Alder reaction for example as described by Padwa, A.; Dimitroff, M.; Waterson, A. G.; Wu, T.; J Org Chem 1997, 62, 4088-4096 and subsequent hydrogenation as described by Ansell, M. F.; Caton, M. P. L.; North, P. C.; Tetrahedron Lett. 1982, 23, 2811) and bromoacetonitrile with the exception that acetone was used as solvent in place of DMF. The substance was employed as crude product in the next reaction.

後処理

  1. customSynthesis
  2. customfrom Diels-Alder reaction for example
  3. customThe substance was employed as crude product in the next reaction

出典と根拠

ORDレコード
ord-5397b9d01bdc473a8cd5f7b98554a071
出典データセット
uspto-grants-2005_06
特許番号
US06903089B1

関連ノート

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