Sodium Carbonate → 3,6,8-Tribromoimidazo[1,2-a]pyrazine

HRID 1086174ノート

反応式

HRID 1086174 の反応式
[Br:1][C:2]1[N:3]=[C:4]([Br:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:12]N1C(=O)CCC1=O.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:12][C:8]1[N:6]2[CH:7]=[C:2]([Br:1])[N:3]=[C:4]([Br:11])[C:5]2=[N:10][CH:9]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 67184N-bromobutanimideHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

生成物 1

HCID 142076223,6,8-Tribromoimidazo[1,2-a]pyrazine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 0.8 g (2.9 mmol) of 6,8-dibromoimidazo[1,2-a]pyrazine and 1.2 g of N-bromosuccinimide in 40 ml of chloroform is brought to reflux for two hours. After being cooled, the organic solution is treated with aqueous Na2CO3 solution. The chloroform phase is collected and then evaporated. 1 g -(Yld=97%) of 3,6,8-tribromoimidazo[1,2-a]pyrazine (m.p. 161° C.) is obtained.

後処理

  1. temperatureto reflux for two hours
  2. temperatureAfter being cooled
  3. customThe chloroform phase is collected
  4. customevaporated

出典と根拠

ORDレコード
ord-6ae912ba9eb44bfab634123c48a48334
出典データセット
uspto-grants-1991_07
特許番号
US05028605

反応ノート

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