Methyl iodide → methyl 4-((1-methyl-1H-indol-3-yl)methyl)benzoate

HRID 1163096ノート

反応式

HRID 1163096 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=2)=[CH:2]1.[H-].[Na+].[CH3:23]I>C1COCC1>[CH3:23][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]2[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=2)=[CH:2]1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 26367194methyl 4-((1H-indol-3-yl)methyl)benzoate

生成物 1

HCID 58970761methyl 4-((1-methyl-1H-indol-3-yl)methyl)benzoate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of methyl 4-((1H-indol-3-yl)methyl)benzoate (0.250 g, 0.94 mmol) in THF is added dropwise to a suspension of NaH (0.048 g, 1.19 mmol) in THF. The mixture is stirred for 15 minutes, treated with methyl iodide (0.154 g, 1.08 mmol), stirred for 30 minutes and concentrated in vacuo. The resultant solid residue is partioned between CH2Cl2 and H2O. The organic phase is separated, dried over Na2SO4 and concentrated to dryness to yield methyl 4-((1-methyl-1H-indol-3-yl)methyl)benzoate.

後処理

  1. stirringstirred for 30 minutes
  2. concentrationconcentrated in vacuo
  3. customThe organic phase is separated
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-0c72bbc334f348298ae8a70e538aa13d
出典データセット
uspto-grants-2010_10
特許番号
US07820825B2

反応ノート

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