Cyclohexene → N-(piperidin-4-yl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide

HRID 1167099

反応式

HRID 1167099 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:18]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.C1CCCCC=1>C(O)C.CO.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[C:18]([C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:30])([F:31])[F:32])=[CH:27][CH:28]=3)=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:16])[CH2:10][CH2:9]1

参加物

6

反応物 2

HCID 8079CyclohexeneHCID 229956921-Benzyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)piperidine

生成物 1

HCID 9928271N-(piperidin-4-yl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide

試薬・触媒・溶媒 3

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

31.6 g (0.072 mol) of 4′-trifluoromethyl-biphenyl-2-carboxylic acid-(1-benzyl-piperidin-4-yl)-amide are dissolved in 180 ml ethanol and 180 ml methanol, mixed with 84 ml (0.83 mol) of cyclohexene and 6.53 g of palladium hydroxide (20% on charcoal) and refluxed for four hours. The hot reaction mixture is filtered through kieselguhr and the reaction mixture is concentrated by rotary evaporation.

後処理

  1. temperaturerefluxed for four hours
  2. filtrationThe hot reaction mixture is filtered through kieselguhr
  3. concentrationthe reaction mixture is concentrated by rotary evaporation

出典と根拠

ORDレコード
ord-106d94eed4db4e3c9eaca0aec285400e
出典データセット
uspto-grants-2003_09
特許番号
US06617325B1

関連ノート

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