(-)-2-Aminobutyric acid → (s)-4-Ethyloxazolidine-2,5-dione
反応式
[NH2:1][C@@H:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].Cl[C:9](Cl)([O:11]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCCC1>[CH2:6]([C@H:2]1[C:3](=[O:5])[O:4][C:9](=[O:11])[NH:1]1)[CH3:7]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a suspension of (2S)-2-aminobutanoic acid (10 g) and activated carbon (116 mg) in tetrahydrofuran (50 mL) was added dropwise a solution of triphosgene (10.07 g) in tetrahydrofuran (50 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The same experimental process was performed twice, in each of which insoluble materials were filtered off with celite, and the filtrates were combined and concentrated under reduced pressure. The residue was washed with hexane to give the title compound as a solid (yield: 22.39 g, 89%).
後処理
- filtrationin each of which insoluble materials were filtered off with celite
- concentrationconcentrated under reduced pressure
- washThe residue was washed with hexane
出典と根拠
- ORDレコード
- ord-06a822ca587e46c488715856a1c16c04
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834051B2
反応ノート
読み込み中…